Effect of cadmium on CNS function and development in rat offspring: effect of vitamin E
Iraqi Journal of Veterinary Sciences,
2008, Volume 22, Issue 1, Pages 31-37
AbstractThe work was designed to study the effect of vitamin E ( 500 mg /kg diet ) on the central nervous system function and landmarks development in offspring of rats whoser mothers treated with cadmium (50mg/L of drinking water) during lactation. Cadmium chloride caused a significant increase in righting reflex , olfactory discrimination tests in pups (aged one week) and in the onset of movement test in weaned pups. The results indicated a significant reduction in motor activity in the open field, cliff avoidance, click response and weight in weaned pups. Cadmium chloride caused a significant increased in negative geotaxic in weaned pups. Cadmium chloride did not affect significantly on landmarks development ( opening of eyes and ears , appearance of teeth and hair) with the exception of a significant increase in descending time of testis and a significant decrease in appearance time of vaginal opening . Administration of vitamin E caused a significant increase in motor activity in the open field. and significant reduction in the onset of movement test, negative geotaxic and weight of weaned pups and in descending time of testis . It is concluded from this study that vitamin E caused positive effects on central nervous system and some landmarks development in pups whose their mothers treated with cadmium chloride.
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