Effect of garlic oil as antiatherogenic on intiation and development of atherosclerosis induced experimentally by oxidative stress in rabbit
Iraqi Journal of Veterinary Sciences,
2005, Volume 19, Issue 2, Pages 179-192
AbstractThis study searched the microscopical effects of garlic oil at a dose of 50 mg daily for 60 days on tissues of heart , liver, and kidney in female rabbits. The results revealed hyperatrophy in cardiac myocyte, acute cell swelling in hepatocyte and epithelial cells that lined renal tubules. Complete lipid profile was also described.
The study also proved that garlic oil had a good antioxidant effects toward the meliorating progression of atherumatous lesion. Antioxidative effects also explained by significant reduction in lipid profile parameters (except an elevation in HDL-C), as well as elevation in tissue GSH and reduction of tissue MDA, as compared with control group. One more result , this study was suggest on the therapeutic efficiency of garlic oil and vitamin E for 15 days after exposure to hydrogen peroxide for 60 days. The therapeutic effects interpret within the significant reduction in the level of total cholesterol, triglyceride, LDL-C, VLDL-C, atherogenic index and significant increase in the level of HDL-C. In addition to significant increase in the level of GSH and significant decrease in the level of MDA. The histopatholgical changes, reveled less reduction in atherosclerotic lesions. This study concluded that garlic oil have a capability to decrease the level of lipid profile as antiatherogenic. In addition, the ability to decrease the level of lipid peroxidation MDA, and to increase the level of GSH as antioxidant.
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