Curative and protective potentials of decoction of Moringa oleifera leaf on the streptozotocin-Induced Diabetes mellitus in albino Rats
Iraqi Journal of Veterinary Sciences,
The present study was designed to investigate the protective and curative potentials of Moringa oleifera (MO) leaves powder against streptozotocin (STZ) induced type 1 diabetes mellitus (T1DM) in rats. Fifty adult Wistar male albino rats were randomized divided into five equal groups: The normal control group, the Moringa group, The diabetic group, the therapeutic group, the diabetic rats (3 days after STZ injection) were received MO for successive 8 weeks and the prophylactic group, the rats were received MO for 2 weeks before STZ induced diabetic rats and lasted for 8 weeks. The protective or treated oral administration of 1 ml freshly prepared aqueous leaf decoction of MO revealed a significant upregulation on the mRNA expression of PDX-1, Ngn3, VEGF, IGF-1 and GLUT-2. Additionally, it induced a significant downregulation of FBG level in comparison with that of the diabetic group as well as a significant reduction in the level of MDA and a significant elevation in the TAC level. Furthermore, the histopathological observations of pancreas, liver and kidneys tissues affirmed the improvement in treated and prophylactic groups in comparison with STZ-diabetic groups and the improvement in prophylactic group was most distinct than treated group.MO aqueous leaf extract can treat and protect against STZ-induced T1DM, via its antioxidant action (increase the TAC and decrease MDA). Thus, it has the potential for utilization as a prophylactic against diabetes.
Diabetes mellitus (DM),,
,،,؛Liver and kidney,,
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