The impact of Nano Zinc oxide particles on the histology of male reproductive system of adult male rabbits
Iraqi Journal of Veterinary Sciences,
The goal of our research is evaluating histological impact of nano ZnO particles (NZnO) on the testis and epididymis of adult male rabbits treated with intraperitoneal of 600mg/kg B.W. of nano ZnO particles twice a week for six weeks and illustrate the protective effect of vitamin E versus the effect of nano zinc oxide particles. Twenty-four adult male rabbits have been used in this research divided to four groups, control group injected intraperitoneal distal water, second group injected with 600mg/kg B.W of nano Zno particles intraperitoneal twice a week for three weeks, third group injected 600 mg / kg B.W. of nano Zno particles intraperitoneal and co-administrated with 100 mg / kg B.W. of vitamin E orally, while fourth group received 100mg/kg B.W of vitamin E orally. The histological results showed that the nano ZnO particles treatment cause obvious changes in testis and epididymis characterized by thickening of tunica albuginea of testis, degenerative and necrotic changes of germ cells lining the seminiferous tubules, arrest of spermatogenesis, giant cell formation also observed, degeneration and necrosis of epithelial cells lining epididymis canals, the canals are free from sperms is observed. As for the group of animals treated with nano ZnO particles co-administrated with vitamin E showed improvement in the histological changes compared with control group and group treated with vitamin E only which showed normal architectural of testis and epididymis, moreover there is decreased in the level concentration of testosterone of the animals treated with nano ZnO particles compared with other groups.
Nano ZnO particles,,
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