Amelioration activity of vitamin E in rabbits with brain histological alteration induced by zinc-oxide nanoparticles
Iraqi Journal of Veterinary Sciences,
The Zinc-oxide in the form of nanoparticles suggested to be one of the crucial nanoparticles due to its expanse implementation in many industries, like electrons, food supplements, and maquillage and makeup this led to more exposure of the individual to ZnO NPs through inspiration, and skin penetration. This study object or designed to estimate the toxic impact of ZnO NPs on cerebral cortex, hippocampus, and cerebellum in male rabbits by studying the gross and histological changes by using the light microscope. 24 adult male rabbits divided randomly to 4 groups, each of them comprising six animals. Control group left without treatment; second group treated with 100 mg / kg B.W. of vitamin E orally, third group treated intraperitonially with ZnO NPs 600mg/kg B.W., Fourth group treated with I/P 600mg/kg B.W. of ZnO NPs in addition to 100mg/kg B.W orally of vit. E twice weekly for twenty-one days. The histological results showed degenerative, necrotic with vascular and inflammatory response in cerebral cortex, hippocampus and cerebellum in 2nd group of rabbits treated with ZnO NPs while the treated rabbits with ZnO NPs and vitamin E revealed slight improvement in histological picture of brain layers. Also, there was alteration in the level of acetylcholine in all groups in comparing with control group.
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