Comparing efficacy of the platelet rich plasma and advanced platelet rich fibrin on tibial bone defect regeneration in dogs
This study aimed to evaluate the efficacy of platelet rich plasma (PRP) and advanced platelet rich fibrin (A-PRF) on regeneration of induced tibial bone defects in dogs. A 7mm circular tibial defect and 10mm depth was performed at the proximal extremity of the right and left tibiae of 12 adult apparently healthy male mongrel dogs. The animals were divided into control group, PRP group and A-PRF group. Regeneration of the tibial defect was evaluated by radiographic, computed tomography (CT), gross and histopathological examination at 6 and 12 weeks postoperatively (PO). At 6 weeks PO, the tibial defect was partially filled with fibrous tissue and appeared radiolucent radiographically in the control group and were partially closed with newly formed bone and appeared more radiopaque in PRP group than the control group while tibial defect was completely closed with newly formed bone and appeared more radiopaque in A-PRF group than the PRP group. At 12 weeks PO, the tibial defect was partially filled with newly formed bone and appear more radiopaque in control group and completely closed with newly formed bone and appeared radiopaque in PRP group. Interestingly, the tibial defect of the A-PRF group was completely closed with newly formed bone and cannot be differentiated from the neighboring normal bone tissue. In conclusion, using of PRP and A-PRF improved bone healing. However, A-PRF improved early regenerative ability of the tibial defect in comparison to PRP.
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