College of Veterinary Medicine / University of Mosul
  • Register
  • Login
  • العربیة

Iraqi Journal of Veterinary Sciences

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Articles in Press
  3. Author

Current Issue

By Issue

By Subject

Keyword Index

Author Index

Indexing Databases XML

About Journal

Aims and Scope

Editorial Board

Editorial Staff

Facts and Figures

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

News

Gonadotropin Profile in Experimentally Induced Hypothyroid and Hyperthyroid Cyclic Female Rats

Iraqi Journal of Veterinary Sciences, In Press
10.33899/ijvs.2022.131830.2007

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Current study was conducted to examine the association of thyroid disorders with reproductive dysfunction, by determining its effect on gonadotropins secretion in cyclic female rats. Sixty cyclic females were assigned to three groups (20 each) and drenched, for 30 days plus 2 consequent estrous cycles, with drinking water (control), methimazole in drinking water (0.02% w/v) (hypothyroid group), and thyroxin in drinking water (0.002% w/v) and gastric gavage of thyroxin (200 μg/kg bw) (hyperthyroid group). At late proestrus, 10 females from each group (for each cycle) were anesthetized, dissected, and blood samples were obtained for assessment of thyroid stimulating hormone, free and total triiodothyronine, free and total thyroxin, follicle stimulating hormone, luteinizing hormone, and prolactin concentrations. Ovarian and pituitary tissue samples were obtained for molecular analysis of ovarian thyroid receptor genes and pituitary TSH, FSHβ, and LHβ genes. In comparison with control, Hypo group revealed increased serum concentrations of TSH and PRL and the expression levels of pituitary TSH and ovarian TRs genes and significant decrease of FT3, TT3, FT4, TT4, FSH, and LH concentrations and the expression levels of pituitary FSHβ and LHβ genes, whereas Hyper group showed increased serum FT3, TT3, FT4, TT4, and LH concentrations and the expression levels of pituitary LHβ and ovarian TRs genes and decreased serum TSH, FSH and PRL concentrations and pituitary FSHβ and TSH gene expression levels. It is concluded that thyroid dysfunction is associated with altered serum gonadotropin secretion and reproductive failure.
Keywords:
    Thyroid dysfunction,, ,،,؛Hypothyroidism,, ,،,؛Hyperthyroidism,, ,،,؛Gonadotropin,, ,،,؛Reproduction
Main Subjects:
  • Animal Physiology
  • PDF
  • XML
(2022). Gonadotropin Profile in Experimentally Induced Hypothyroid and Hyperthyroid Cyclic Female Rats. Iraqi Journal of Veterinary Sciences, (), -. doi: 10.33899/ijvs.2022.131830.2007
. "Gonadotropin Profile in Experimentally Induced Hypothyroid and Hyperthyroid Cyclic Female Rats". Iraqi Journal of Veterinary Sciences, , , 2022, -. doi: 10.33899/ijvs.2022.131830.2007
(2022). 'Gonadotropin Profile in Experimentally Induced Hypothyroid and Hyperthyroid Cyclic Female Rats', Iraqi Journal of Veterinary Sciences, (), pp. -. doi: 10.33899/ijvs.2022.131830.2007
Gonadotropin Profile in Experimentally Induced Hypothyroid and Hyperthyroid Cyclic Female Rats. Iraqi Journal of Veterinary Sciences, 2022; (): -. doi: 10.33899/ijvs.2022.131830.2007
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 32
  • PDF Download: 0
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

© 2022, College of Veterinary Medicine, University of Mosul

 
This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus