Iraqi Journal of Veterinary Sciences

Abstract

Prednisolone is a synthetic corticosteroid used to treat different diseases. They are well known to be used for remediation of many cases like autoimmune diseases, asthma. Cyclophosphamide is a kind of nitrogen mustard treatment that occurs its effects by the alkylation of DNA. It is used as an immunosuppressant in rheumatoid arthritis and the remediation of many cancers as well. The aim of this study is to histological compare the side effects of these two drugs. Seventy-five adult mice were used in this experiment which was divided into three groups, the first group orally treated with 0.1mg/Kg of prednisolone, the second group orally treated with 0.1mg/kg of body weight cyclophosphamide, and the third group received orally distilled water for 30 days. After 24 hours of the last treatment, the animals were sacrificed and the organs (liver, kidney, small intestine) were taken out and placed in 10% formalin solution until histological techniques were performed on them. Results of the study demonstrated histological changes in studied organs when treated the animals with prednisolone and cyclophosphamide represented by congestion and hemorrhage of blood vessels and sinusoids, cellular inflammation and necrosis, and that there is a significant difference for these histological alterations between the prednisolone, cyclophosphamide and controls mice. Our study confirms that these drugs cause histological alterations and that cyclophosphamide has a histological side effect more than prednisolone.