College of Veterinary Medicine / University of Mosul
  • Register
  • Login
  • العربیة

Iraqi Journal of Veterinary Sciences

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Articles in Press
  3. Authors

Current Issue

By Issue

By Subject

Keyword Index

Author Index

Indexing Databases XML

About Journal

Aims and Scope

Editorial Board

Editorial Staff

Facts and Figures

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

News

Histological changes comparison between the toxic effect of Prednisolone and Cyclophosphamide drug on some organs in male albino mice

    Sahar A. H. AL-Sharqi Amal Kadhem Chaloob Ilham Abd Allah Ali Al-Saleem

Iraqi Journal of Veterinary Sciences, In Press
10.33899/ijvs.2021.131292.1938

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Prednisolone is a synthetic corticosteroid used to treat different diseases. They are well known to be used for remediation of many cases like autoimmune diseases, asthma. Cyclophosphamide is a kind of nitrogen mustard treatment that occurs its effects by the alkylation of DNA. It is used as an immunosuppressant in rheumatoid arthritis and the remediation of many cancers as well. The aim of this study is to histological compare the side effects of these two drugs. Seventy-five adult mice were used in this experiment which was divided into three groups, the first group orally treated with 0.1mg/Kg of prednisolone, the second group orally treated with 0.1mg/kg of body weight cyclophosphamide, and the third group received orally distilled water for 30 days. After 24 hours of the last treatment, the animals were sacrificed and the organs (liver, kidney, small intestine) were taken out and placed in 10% formalin solution until histological techniques were performed on them. Results of the study demonstrated histological changes in studied organs when treated the animals with prednisolone and cyclophosphamide represented by congestion and hemorrhage of blood vessels and sinusoids, cellular inflammation and necrosis, and that there is a significant difference for these histological alterations between the prednisolone, cyclophosphamide and controls mice. Our study confirms that these drugs cause histological alterations and that cyclophosphamide has a histological side effect more than prednisolone.
Keywords:
    Prednisolone,, ,،,؛Cyclophosphamide,, ,،,؛Liver,, ,،,؛Kidney,, ,،,؛Small intestinal
Main Subjects:
  • Animal Histology
  • PDF
  • XML
(2022). Histological changes comparison between the toxic effect of Prednisolone and Cyclophosphamide drug on some organs in male albino mice. Iraqi Journal of Veterinary Sciences, (), -. doi: 10.33899/ijvs.2021.131292.1938
Sahar A. H. AL-Sharqi; Amal Kadhem Chaloob; Ilham Abd Allah Ali Al-Saleem. "Histological changes comparison between the toxic effect of Prednisolone and Cyclophosphamide drug on some organs in male albino mice". Iraqi Journal of Veterinary Sciences, , , 2022, -. doi: 10.33899/ijvs.2021.131292.1938
(2022). 'Histological changes comparison between the toxic effect of Prednisolone and Cyclophosphamide drug on some organs in male albino mice', Iraqi Journal of Veterinary Sciences, (), pp. -. doi: 10.33899/ijvs.2021.131292.1938
Histological changes comparison between the toxic effect of Prednisolone and Cyclophosphamide drug on some organs in male albino mice. Iraqi Journal of Veterinary Sciences, 2022; (): -. doi: 10.33899/ijvs.2021.131292.1938
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 33
  • PDF Download: 0
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

© 2022, College of Veterinary Medicine, University of Mosul

 
This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus