Iraqi Journal of Veterinary Sciences

Abstract

This study examines and evaluates the interaction between imidocarb and diphenhydramine on the level of cholinesterase activity and small intestinal transit (SIT) in chicks. Imidocarb at 45 mg/kg,s.c. significantly inhibited plasma and brain cholinesterases, 30 min after injection by 69 and 21%, respectively. Diphenhydramine at 5 mg/kg, s.c significantly inhibited plasma and brain cholinesterase by 29.7 and 35.7%, respectively and significantly decreased the inhibitory effect of imidocarb on plasma cholinesterase by 33.2%. Imidocarb at 40 mg/kg, s.c. significantly increased SIT 15 and 30 min after injection by 92, 100%, respectively. Diphenhydramine at 5 and 10 mg/kg, s.c., 15 min before imedocarb at 40mg/kg, s.c. significantly decreased SIT produced by imidocarb alone by 80.6 and 70.5 %, respectively and prevented the SIT when given immediately after imedocarb at 40 mg/kg, s.c. by 100%.The data revealed that diphenhydramine has a beneficial effect in controlling the SIT modulated by imidocarb in chicks and there was no adverse interaction between two drugs at the level of cholinesterase.