Histopathological Effects Of Experimental Exposure To Lead On Nervous System In Albino Female Rats
Iraqi Journal of Veterinary Sciences,
Background: Lead toxicity is a common health issue, Lead (pb) is harmful to vital organs of body particularly the nervous system. This study aimed to estimate the effects of lead on the cerebellum , cerebrum and spinal cord in rat model, focusing on histopathological changes. Material &methods: 24 female mature albino rats of 200-300g randomly divided into 2 groups, the first is the control , and the second group were treated with lead acetate at dose 40mg/kg B.W. for 30 days. The results: Microscopic examination revealed degeneration and necrosis of purkinje cells and molecular cells , Decrease in the number of granular cells and molecular cells also observed . Some purkinje cells lose axons and shrinked and some areas showed depletion from purkinje cells, Congestion of blood vessels with perivascular cuffing of mononuclear inflammatory, hemorrhage , neurophagia , glial nodules were observed in the brain paranchyma. Demyelination reported in white matter , with microglial infiltration around vertebral canal of spinal cord. This study referred to the increased risk of central nervous system damage due to the exposure to lead.
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