The Effect of Cinnarizine on Histological Outcome, Oxidative Stress Markers and Adhesion Molecules in Experimental Colitis in Rats
Iraqi Journal of Veterinary Sciences,
Ulcerative colitis is chronic, intermittent illness. The current treatment failed to cure the disease which made a need to investigate other drug with minimal side effects. The goal of the research is to assess the histological outcome, antioxidant and anti-inflammatory effects of Cinnarizine in comparison with that of sulfasalazine in experimental colitis in rats. Acetic acid 4% (vol/vol) was used rectally to induce experimental colitis in rats. After induction, rats were administered either sulfasalazine 100mg/kg or cinnarizine 20mg/kg orally for one week. There was estimation of histopathological and macroscopical parameters also the expression of cytokines (TNF-α and IL-4), oxidative stress markers, malondialdehyde (MDA) and myeloperoxidase (MPO), and adhesion molecules (ICAM-1and E-Selectin) in the colonic tissue. Results showed that both cinnarizine and sulfasalazine significantly reduced the macroscopical and histological injury in colon that induced by acetic acid. Inaddition to the downregulation of the increased colonic proinflammatory cytokines, MDA, MPO parameters and adhesive molecules.These results concluded that cinnarizinehad effective role in experimental colitis in rats through anti-inflammatory and antioxidant actions with downregulation the colonic adhesive molecule.
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