Histological alteration of male and female reproductive systems induced by alloxan in rats
Iraqi Journal of Veterinary Sciences,
The objective of this study is to determine the effect of oxidative stress experimentally induced by alloxan 100 mg/kg bw on the histopathological structure of reproductive organs of male and female albino rats. The results showed that treatment with alloxan cause alteration on tests include irregular shape and size of seminiferous tubules, irregular division of spermatid cells, degeneration and necrosis of Sertoli cells with paucity of sperms into the lumen of tubules. While histological examination of epididymis showed the lumen of it free from sperms, thickening of muscular layer and interstitial tissue between the epididymis canal. As for the histological alteration of female reproductive organs include disturbances in development of primary follicles of ovaries, hemorrhage in the interstitial tissue as well as atrophy in the uterine glands with hyperplasia of the epithelial cells of uterus. The conclusion of this study showed that alloxan cause histological alteration in reproductive organs of male and female rats.
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