The relationship between HSP70 and level of leptin and luteinizing hormones in female rats exposed to chronic and acute heat stress
Iraqi Journal of Veterinary Sciences,
2020, Volume 34, Issue 1, Pages 37-43
AbstractThe current search experiments designed to study the effect of chronic and acute heat stress on the relationship between HSP70, leptin and luteinizing hormones level in female rats. 45 female pups were used in the age of weaning, were randomly divided into three equal groups. 1st group was a control group, 2nd group exposed to chronic heat stress at 38 ºC for 1hour a day since the age of weaning until onset of puberty and the 3rd group exposed to acute heat stress at 38 ºC for 4 hours per day for 5 consecutive days from 35 day age of rat and each group above were secondary divided into 3 age groups consisted of pre-puberty, at puberty and post-puberty. Results of study showed female rats exposed to chronic and acute stress led to significant increase in the level of luteinizing hormone at onset of the puberty. The result showed correlation coefficient between the level of HSP70 and leptin hormone significantly in the females acute stressed group at onset of puberty, as well as female exposed to chronic heat stress led to significant correlation coefficient between HSP70 and leptin hormone at post puberty. The result revealed significant correlation coefficient between HSP70 and luteinizing hormone in female control group at onset of puberty. It concluded from this study there is relationship between HSP70 and leptin hormone at onset puberty during acute heat stress and same relationship at post puberty during chronic heat stress.
- Dey PK. Involvement of endogenous opiates in heat stress. Biomed. 2000; 20:143-148.
- Aggarawal Y, Karan BM, Das BN, Sinha RK. Mechanistic electronic model to simulate and predict the effect of heat stress on the functional genomics of HO-1 system: Vasodilation. Comp Biol Med. 2010; 40:533-42.https//doi.org/10.1016/j.compbiomed.2010.03.011
- Westman J, and Sharma HS. Heat shock protein response in the CNS following hyperthermia. Prog Brain Res. 1998; 1215:207-239. http://sci-hub.tw/10.1016/S0079-6123(08)62038-5
- Thomas TC, Kumar VM. Effect of ambient temperature on brain temperature and sleep-wakefulness in medial preoptic area lesioned rats. Ind J Physiol Pharmacol. 2002; 46:287-297.
- Jeanneteau FD, Lambert WM, Ismaili N, Bath KG, Lee FS, arabedian MJ, Chao M. VBDNF and glucocorticoids regulate corticotropin- releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci. 2012; 109:1305-1310. http://sci-hub.tw/10.1073/pnas.1114122109
- Moseley PL. Heat shock proteins and heat adaptation of the whole organism. J Appl Physiol. 1997; 83(5):1413-1417. http://sci-hub.tw/10.1152/jappl.1922.214.171.1243
- Marieb EN, and Katja H. Human anatomy and physiology. 7th ed. San Francisco: Mosby; 2007.
- Latchman DS. Heat shock proteins and cardiac protection. Cardiovasc Res. 2001; 51(4):637-646. doi.org/10.1016/S0008-6363(01)00354-6
- Zhou XC, Zhang ZH, Hu ZY, Zou RJ, Liu YX. Expression of HSP70 in rhesus monkey testis during germ cell apoptosis induced by testosterone undecanoate. Contra. 2002; 66(5):377-382. http://sci-hub.tw/10.1016/S0010-7824(02)00357-8
- Hightower LE. Heat shock, stress protein, chaperones, and proteotoxicity. Cell. 1991; 66(2):191-197. http://sci-hub.tw/10.1016/0092-8674(91)90611-2
- Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW.Central nervous system control of food intake and body weight. Nature. 2006; 443(7109):289-295.
- Dalamaga M, Chou SH, Shields K, Papageorgiou P, Polyzos SA, Mantzoros CS. Leptin at the intersection of neuroendocrinology and metabolism: Current evidence and therapeutic prespectives. Cell Metabo. 2013; 18(1):29-42. ttps://doi.org/10.1016/j.cmet.2013.05.010
- Salzmann C, Otis M, Long H, Roberge C, Gallo N, Walker CD. Inhibition of steroidogenic response to adrenocorticotropin by leptin: implications for the adrenal response to maternal separation in neonatal rats. Endocrinol. 2004; 145(4):1810-1822. http://sci-hub.tw/10.1210/en.2003-1514
- Chan JL, Mantzoros CS. Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lanc. 2005:366(9479):74-85. http://sci-hub.tw/10.1016/S0140-6736(05)66830-4
- Patani PV, Ghaisas MM, Molvi KI, Seth AK. The physiological role of leptin: A review. JPSBR. 2012; 2(4):162-168.
- Heretier A, Charnay Y, Aubert ML. Regional distribution of mRNA encoding the long form of receptor in mouse brain. Neurosci Res Comm. 1997; 21(2):113-118. http://sci-hub.tw/10.1002/(SICI)1520-6769(199709/10)21:2%3C113::AID-NRC214%3E3.0.CO;2-5
- Sinha RK. Heat acclimation alters the sleep and behavior based thermoregulatory dynamics of rats in heat stress. Med Sci. 2013; 1(3):50-61. http://dx.doi.org/10.29387/ms.2013.1.3.50-61
- Agrawal S, Gupta D. Behavioral changes in albino rats due to repetitive heat stress of moderate level. Inter J Med Sci Pub Heal. 2013; 2(3):650-653.
- Nageeb M. The distribution of GnRH and ER beta in pre and post pubertal male rats [master's thesis]. Chicago: Loyola University; 2010. 18-37 p.
- Steel RGD, Torrie JH, Dickey DA. Principles and procedures of statistics: A biometrical approach. 3rd ed. New York: McGraw Hill; 1986. 481.
- Perez CM, Ramirez MA, Fernandez GR, Rizos D, Lonergan P, Pintado B, Gutierrez AA. Differential sensitivity of male and female mouse embryos to oxidative induced heat-stress is mediated by glucose-6-phosphate dehydrogenase gene expression. Molecular Reprod Develo: Incorp Gamete Res. 2005; 72(4):502-510. http://sci-hub.tw/10.1002/mrd.20366
- Roth Z, Meidan R, Sharham AA, Braw TR, Wolfenson D. Delayed effect of heat stress on steroid production in medium-sized and preovulatory bovine follicles. Reprod. 2001; 21(5):745-751.
- Otaka M, Okuyama A, Otani S, Jin M, Itoh S, Itoh H, Iwabuchi A, Sasahara H, Odashima M. Differential induction of HSP60 and HSP72 by different stress situations in rats (Correlation with cerulein - induced pancreatitis). Dig Dis Sci. 1997; 42(7):1473-1479.
- Pampori ZA, Huozha R, Shah KA, Andrabi SA, Amin T. Stress versus reproduction in animals. J Vet Scan. 2010; 5(2):61.
- Walczewska A, Yu WH, Karanth S, McCann SM. Estrogen and leptin have differential effects on FSH and LH release in female rats. Proc Soc Exp Biol Med. 1999; 222(2):170-177. https://doi.org/10.1177%2F153537029922200209
- Stice J, Knowlton A. Estrogen, NFkB, and the heat shock response. Mol Med. 2008; 14(7-8):517-727.
- Kolaczynski JW, Ohannesian JP, Considine RV, Marco CC, Caro JF. Response of leptin to short-term and prolonged overfeeding in humans. J Clin Endocrinol Metabol. 1996; 81(11):4162-4165. http://sci-hub.tw/10.1210/jcem.81.11.8923877
- Nakhgavani M, Morteza A, Nargesi AA, Mostafavi E, Esteghamati A. Appearance of leptin HSP70 correlation in type 2 diabetes. Meta Gene. 2013; 1:1-7. http://sci-hub.tw/10.1016/j.mgene.2013.09.002
- Dearth RK, Hiney JK, Dees WL. Leptin acts centrally to induce the prepubertal secretion of luteinizing hormone in the female rat. Pept. 2000; 21(3):387-392. http://sci-hub.tw/10.1016/S0196-9781(00)00157-1
- Kalamar B, Greensmith L. Induction of heat shock protein for protection against oxidative stress. Adv Drug Del Rev. 2009; 61(4):310-318. http://sci-hub.tw/10.1016/j.addr.2009.02.003
- Basdevant A, Ciangura C. Leptin: from gene to energy balance. Exp Clin Endocrinol Diab. 2007; 115:423-7.
- Seeber RM, Smith JT, Waddell BJ. Plasma leptin-binding activity and hypothalamic leptin receptor expression during pregnancy and lactation in the rat. Biol Reprod. 2002; 66:1762-1767. http://sci-hub.tw/10.1095/biolreprod66.6.1762
- Ryan MT, Pfanner N. HSP70 proteins in protein translocation. Adv Protein Chem. 2002; 59:223-242. http://sci-hub.tw/10.1016/S0065-3233(01)59007-5
- Roberts SP, Feder ME. Natural hyperthermia and expression of HSP70 affect developmental abnormalities in drosophila melanogaster. Oecol. 1999; 12(3):323-329.
- Article View: 172
- PDF Download: 200