College of Veterinary Medicine / University of Mosul
  • Register
  • Login
  • العربیة

Iraqi Journal of Veterinary Sciences

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 33, Issue 2
  3. Authors

Current Issue

By Issue

By Subject

Keyword Index

Author Index

Indexing Databases XML

About Journal

Aims and Scope

Editorial Board

Editorial Staff

Facts and Figures

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

News

Experimental detection of antioxidant and atherogenic effects of grapes seeds extracts in rabbits

    Shihaab Al-Bajari Moataz Al- Akash Hana Kh. Ismail

Iraqi Journal of Veterinary Sciences, 2019, Volume 33, Issue 2, Pages 243-249
10.33899/ijvs.2019.162881

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

The aim of this study was to determine the ability of Grapes seeds (Vitis vinifera) aqueous, proteinous, non- proteinous and alcoholic extracts as antioxidant and antiatherogenic in rabbits after exposure to 0.5% H2O2 in drinking water for 30 days. The results illustrated capability of 0.5% H2O2 to initiate oxidative stress via significant decrease in Glutathione (GSH), glutathione peroxdiase (GPx), Catalase (CAT) and superoxide dismutase (SOD) level in heart and liver concomitant with significant increase in malondialhyde (MDA) in addition to decrease in high density lipoprotein- cholesterol (HDL-c) and increase low density lipoprotein- cholesterol (LDL-c) in serum of treated only with H2O2 rabbits. While rabbits treated with H2O2 associated with Grapes seeds (aqueous, proteinous, non- proteinous and alcohol) extracts for 15 days showed a significant increase of Glutathione (GSH), glutathione peroxdiase (GPx), superoxide dismutase (SOD) concentration in the heart and liver tissue as well as increase HDL-c, decrease in LDL-c and VLDL-c. While, the histolopathological examination of heart and liver tissue demonstrated that H2O2 induces, degeneration, necrosis and few inflammation foci in the liver and myocardial muscle. While the administration of (Vitis vinifera) aqueous, proteinous, non-proteinous and alcoholic extracts cause improvement in the histological picture of the liver and the myocardial muscle. It was concluded that the (Grapes extracts) aqueous, proteinous, non-proteinous and especially the alcoholic extracts can reduce the damage caused by H2O2 and this will pave the way to investigate the protective effects of the natural substances in the diseases caused by oxidative stress.
Keywords:
    Grapes seeds lipid peroxidation Antioxidants Oxidative stress
Main Subjects:
  • Veterinary Pathology
  • PDF (1060 K)
  • XML
(2019). Experimental detection of antioxidant and atherogenic effects of grapes seeds extracts in rabbits. Iraqi Journal of Veterinary Sciences, 33(2), 243-249. doi: 10.33899/ijvs.2019.162881
Shihaab Al-Bajari; Moataz Al- Akash; Hana Kh. Ismail. "Experimental detection of antioxidant and atherogenic effects of grapes seeds extracts in rabbits". Iraqi Journal of Veterinary Sciences, 33, 2, 2019, 243-249. doi: 10.33899/ijvs.2019.162881
(2019). 'Experimental detection of antioxidant and atherogenic effects of grapes seeds extracts in rabbits', Iraqi Journal of Veterinary Sciences, 33(2), pp. 243-249. doi: 10.33899/ijvs.2019.162881
Experimental detection of antioxidant and atherogenic effects of grapes seeds extracts in rabbits. Iraqi Journal of Veterinary Sciences, 2019; 33(2): 243-249. doi: 10.33899/ijvs.2019.162881
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 731
  • PDF Download: 575
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

© 2023, College of Veterinary Medicine, University of Mosul

 
This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus