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Iraqi Journal of Veterinary Sciences

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Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails

    Saeed Majed Al-Abady Saevan Saad Al-Mahmood

Iraqi Journal of Veterinary Sciences, Volume 31, Issue 2, Pages 67-71
10.33899/ijvs.2017.145567

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Abstract

In present study, we aimed to investigate the pathological changes induced by subchronic oral toxicity induced by sub lethal dose of Di (2-ethyl hexyl) phthalate (DEHP) in Japanese common quail. Forty male quails at one day old were divided randomly into two equal groups, the first group (treated group) was orally administrated by 10% of LD50 of DEHP (557.41 mg/kg of body weight) for 42 days, while second group (control group) left without treatment throughout experiment period. The results of current study showed that there is congestion of kidney, microscopically they showed presence of hyaline degeneration in renal tubules, glomerulosclerosis, wide spread of degenerative and necrotic lesions in renal tubules, hemorrhage, infiltration of inflammatory cell especially macrophages and lymphocytes in interstitial tissue of kidney. While grossing of liver showed hepatomegaly with hemorrhage, microscopically the sections showed wide distributing of vacuolar degeneration (fatty change) in different size and shape of vacuoles in cytoplasm of affected hepatocytes, infiltration of inflammatory cells mainly macrophages and lymphocytes. In conclusion, the oral administration of DEHP at dose 557.41 mg/kg of body weight for 42 days induced degenerative and necrotic irreversible changes in both kidney and liver of Japanese quail that affect their health and production.
Keywords:
    Pathology Subchronic toxicity DEHP Quails kidney liver
Main Subjects:
  • Poultry Vaccine and Biosecurity
  • Veterinary Pathology
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(2017). Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails. Iraqi Journal of Veterinary Sciences, 31(2), 67-71. doi: 10.33899/ijvs.2017.145567
Saeed Majed Al-Abady; Saevan Saad Al-Mahmood. "Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails". Iraqi Journal of Veterinary Sciences, 31, 2, 2017, 67-71. doi: 10.33899/ijvs.2017.145567
(2017). 'Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails', Iraqi Journal of Veterinary Sciences, 31(2), pp. 67-71. doi: 10.33899/ijvs.2017.145567
Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails. Iraqi Journal of Veterinary Sciences, 2017; 31(2): 67-71. doi: 10.33899/ijvs.2017.145567
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