Iraqi Journal of Veterinary Sciences

Abstract

The aim of this study was to investigate the histopathological side effects of doxorubicin on pancreas tissue in male albino
rats Rattus norvegicus. This study were used 55 adult rats (2.5-3.5) month of age. The rats divided into two groups, the first
group include (35) rats. The second group were (20) rats. Microscopial examination of pancreas lesion demonstrated oedema
around the acini, swelling of the epithelial cells of acini, occurance of cystic fibrosis (mucoviscidosis) at the concentration of
(4,5) mg/kg of body weight ,occurrence of small islets that form of few cells and exocrine-endocrine transformation. There
were thickness in the walls of blood vessels, thrombus, congestion of blood vessels, we conclude, that doxorubicin had
histopathological effect on pancreas in sub-acute doses more than chronic doses.