TY - JOUR ID - 89342 TI - Histopathological effects of doxorubicin on kidneys in rats JO - Iraqi Journal of Veterinary Sciences JA - IJVS LA - en SN - 1607-3894 AU - Ali, I.A. AU - Jumaa, H.J. AD - Y1 - 2014 PY - 2014 VL - 28 IS - 1 SP - 55 EP - 62 DO - 10.33899/ijvs.2014.89342 N2 - The aim of this study was to investigate the histolopathological effect of doxorubicin on rat kidney tissue. The drug was administrated by rats at the dose of (1, 2, 3, 4, 5) mg/kg intrapertonial every (84) hr for the three weeks and the doses of (1, 2, 3) mg/kg intrapertonial every 84 hrs for six weeks. The animals were scarified after 48 hr. of last injection. The study revealed congestion, thrombus, blood vessels hemorrhage, vaculation in the cells of glomerular tuft and tubular, tubuo-interstitial degeneration, tubular casts. The injury score revealed significantly increasing in the degree of injury in glomerules in the animals that received 5 mg/kg of doxorubicin for three weeks and also significantly increasing in the degree of injury in glomerules of the animals that received 3 mg/kg of doxorubicin for six weeks as compared with control animals. We concluded that the doxorubicin has histopathological effect on kidney. UR - https://www.vetmedmosul.com/article_89342.html L1 - https://www.vetmedmosul.com/article_89342_7b2e02d42ff563e82d57bf7a15484c78.pdf ER -