TY - JOUR ID - 116932 TI - The analgesic and anti- inflammatory effects of diphenhydramine in mice JO - Iraqi Journal of Veterinary Sciences JA - IJVS LA - en SN - 1607-3894 AU - Abdulqader, R.F. AD - Y1 - 2014 PY - 2014 VL - 28 IS - 2 SP - 149 EP - 152 DO - 10.33899/ijvs.2014.116932 N2 - The aim of this study discovers the analgesic and anti- inflammatory effects of diphenhydramine in mice that result from formaldehyde injected 1% concentration s/c in right planter of adult mice after 15 minutes of diphenhydramine injection I/M in comparison with control group which it injected with normal saline. Intramuscular injection of diphenhydramine in mice at 1, 2 mg/kg respectively caused analgesia and anti- inflammatory effect that result from pain induced by formaldehyde through significant decrease in licking numbers of formaldehyde injected foot, significantly increase its onset of licking, significant decrease the time elapsed of licking and significant decrease in depth of planter injected foot in comparison with control group. The data of this study suggested that diphenhydramine has anti- inflammatory effect and of analgesic effect in doses 1, 2 mg/ kg I/M in adult mice. UR - https://www.vetmedmosul.com/article_116932.html L1 - https://www.vetmedmosul.com/article_116932_d857f3252de1d53b09e705c2c96e5e1b.pdf ER -