Keywords : Toxicity


Effect of boric acid on sodium fluoride toxicity in chicks

Enaam H. Alabbasi; Yamama Z. Alabdaly

Iraqi Journal of Veterinary Sciences, 2022, Volume 36, Issue 1, Pages 123-131
DOI: 10.33899/ijvs.2021.129497.1653

The aim of this study to explore the therapeutic effect of boric acid on the neurobehavioral (motor activity) level, and histopathologic changes in the brain, liver and kidneys against fluorosis. In this study rose chicks have been used and determined medium lethal sodium fluoride dose at 346.5 mg/kg orally. The chicks divided into four random groups each one consists of 10 chicks. The first group considered to be a control group, the second received 20 mg/kg of sodium fluoride, the third group received 10 mg/kg of boric acid and the fourth received 20 mg/kg of sodium fluoride and boric acid at the same previous dosages. After two weeks of daily treatment, neurobehavioral measures were taken, the use of boric acid has a major effect to improve the neurobehavioral measurement and develop complications of ALT, AST, creatinine, Ca, MDA. The results indicate that boric acid may be a therapeutic agent against the fluoride toxicity of the brain, liver and kidney. This result support by histopathological changes which represented by inflammation, congestion of portal vein and dilation of sinusoids in the liver and vacuolation, vasogenic edema and gliosis in the brain and Kidney of showed segmentation of glomeruli, dilation of Bowman’s space, necrosis of epithelial cells renal tubules and hemorrhage of NaF group, while the liver of the NaF with boric acid group showed an improvement the results of histopathological examination of the liver, brain and kidneys compared to the NaF group alone. The results revealed that boric acid has a preventing effects against fluoride after two weeks of treatment with boric acid.