Keywords : Dexamethasone


Evaluation healing of jejunal anastomosis in preoperative dexamethasone treated dogs

M.D. Kako; A.M. Al-Hasan; A.S. Al-Qadhi

Iraqi Journal of Veterinary Sciences, 2015, Volume 29, Issue 1, Pages 0-0
DOI: 10.33899/ijvs.2015.116857

The objective of this study is to evaluate the healing process of jejunal anastomosis by the aid of histopathology and
measurement of bursting pressure of anastomosis site in thirty two adult preoperatively with dexamethasone. The animals were
randomly divided into 2 equal groups: Group 1: consists of 16 dogs underwent apposition end-to-end jejunal anastomosis
using simple interrupted suture technique which in turn divided into 2 subgroups: subgroup A: consists of 8 dogs treated
preoperatively for 15 days with dexamethasone at a dose of (0.2mg/kg) given I/M. Subgroup B: control group consists of 8
dogs not treated with dexamethasone. Group 2: consists of 16 dogs underwent inverted end-to-end jejunal anastomosis using
continuous Lembert suture pattern that also divided into 2 subgroups: subgroup A: consists of 8 dogs treated preoperatively for
15 days with dexamethasone at a dose of (0.2mg/kg) given I/M. subgroup B: control group consists of 8 dogs not treated with
dexamethasone. The result of bursting pressure measurement showed higher tensile strength in the control groups (445±9.6) in
comparison with the steroidal groups (255±25.3) for both techniques. The histopathological study showed that the healing was good in all groups but the rupture that occur due to shedding the pressure lead to non discrimination between which is better in terms of healing. Massonʼs trichrome showed that collagen content of subgroups taking dexamethasone was lower than that of subgroups not treated with dexamethasone.

Effect of Gundelia tournefortii on some biochemical parameters in dexamethasone-induced hyperglycemic and hyperlipidemic mice

O. H. Azeez; A. E. Kheder

Iraqi Journal of Veterinary Sciences, 2012, Volume 26, Issue 2, Pages 73-79
DOI: 10.33899/ijvs.2012.67458

The aim of this study was conducted to evaluate the effect of Gundelia tournefortii on some biochemical parameters in hyperglycemic and hyperlipidemic mice. Male albino mice were induced hyperglycemic and hyperlipidemic by daily injection of dexamethasone 1 mg/kg of body weight intramuscularly (i.m.), the mice randomly divided into five groups (6-8 mice in each group). The group 1: served as negative control group; the group 2: injected with dexamethasone at dose 1 mg /kg.b.w.i.m and served as positive control group; the groups 3, 4, 5: treated with extract of G. tournefortii at doses: 75, 150, 300 mg/kg.b.w. orally respectively companied with injection of dexamethasone 1 mg/kg.b.w.i.m. All treatment were once daily for 22 days. Dexamethasone treatment lead to significant increase in levels of glucose, cholesterol, and triglyceride, and significant decrease of body weight, without any effect on level of total protein. G. tournefortii extract treatment at doses: 75 mg/kg.b.w. resulted significant decrease levels of glucose, and body weight. Beneficial effect were seen when mice treated with G. tournefortii at dose of 300 mg/kg.b.w. that lead to significant decrease in levels of glucose, triglyceride, and cholesterol. These results indicate the usefulness of G. tournefortii extract as hypoglycemia and hypolipidemia in dexamethasone treated mice.