Keywords : Vitamin E


The histological changes induced by Cytarabine on rabbits livers (with and without vitamin E administration)

Saif Al-Jammas; Ayad Al-Saraj

Iraqi Journal of Veterinary Sciences, 2020, Volume 34, Issue 1, Pages 9-13
DOI: 10.33899/ijvs.2020.163564

The present study was intended to determine the histological changes induced by Cytarabine drug on the structure of rabbit's livers and the protective effects of vitamin E on these histological changes. The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone, showed a massive histological change represented by infiltration of mononuclear inflammatory cells, epithelioid cell and Kupffer's cells in hepatic tissue. Fibrosis in portal area, congestion of blood vessels as well as hyperplasia of bile canaliculi and coagulative necrosis of hepatocytes were also noticed in other sections. While the group that received protective (800 IU of vitamin E) prior to each Cytarabine injection, showed a considerable histological improvement than the group received Cytarabine alone, as the histological sections of this group showed a nearly normal histological architecture of the liver that represented by normal arrangement of hepatic cords, no fibrosis no congested blood vessels were seen. though distension of hepatic sinusoids and coagulative necrosis of some hepatocytes were still observed. The present study suggested that vitamin E is an effective chemo-protective agent against hepatotoxicity when used as a protective agent prior to Cytarabine drug taken.

The histological changes induced by cytarabine on rabbits kidneys (with and without vitamin E administration)

Saif Al-Jammas; ayad Al-Sarraj

Iraqi Journal of Veterinary Sciences, 2019, Volume 33, Issue 2, Pages 311-316
DOI: 10.33899/ijvs.2019.162910

The present study was designed to determine the histological changes induced by Cytarabine drug on the structure of rabbits kidneys and the protective effects of vitamin E on these histological changes. The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone, showed a massive histological changes represented by renal tubular necrosis, glomerular atrophy and enlarged urinary spaces (widening of Bowman’s spaces), infiltration of lymphocytes and macrophages within interstitium of the cortex, formation of hyaline cast in some of the tubular lumens as well as fibrosis and hemorrhage in the cortex were also observed. While the group that received a protective (800 IU of vitamin E) prior to each Cytarabine injection showed a significant improvement that represented by focal regions in the cortex with a normal renal tubules except for a cloudy cell swelling which is a reversible injury, also neither cortical hemorrhage nor hyaline cast formation were seen, in addition to presence of focal areas of normal glomeruli. The present study suggests that vitamin E is an effective chemo-protective agent against nephrotoxicity when used prior to each Cytarabine administration.

Effect of vitamin E and Selenium supplementation on productive and physiological performance of quail fed rations with high level of fat

Duread Younis

Iraqi Journal of Veterinary Sciences, 2019, Volume 33, Issue 1, Pages 1-7
DOI: 10.33899/ijvs.2019.125553.1072

The aim of this study the effect of vitamin E, selenium or both of them /or selenium supplementation on productive and physiological traits of quail fed high fat diets. Three hundred unsexed one day old coturnix japonica quail chicks were used in this study. Chicks were reared in cages placed in semi-opened houses and provided with suitable environmentally conditions. Birds were randomized into four treatments each with three replicates (twenty-five birds in each). Two diets starter and finisher containing 3% fat as a source of energy were used until marketing age (42 days). Feed and water were available ad libitum. The experimental treatments were as follows: T1 standard ration (control), T2 standard ration supplemented with 200 mg vitamin E/kg ration, T3 standard ration supplemented with 0.3 mg sodium selenite/kg ration and T4 standard ration supplemented with 200 mg vitamin E/kg and 0.3 mg sodium selenite/ kg ration. Rations supplemented with vitamin E, sodium selenite or their combination caused a significant increase in average live body weight, weight gain, significant decrease in feed consumption, blood glucose concentration, heart glycogen concentration and ALT, and AST enzymes concentration, significant improvement in feed conversion ratio was noted in birds fed these diets. No significant differences in average feed passage time in the digestive tract, triglycerides, albumin, globulin, total protein, packed cell volume, hemoglobin concentration, red blood cells account, dressing percentage, liver glycogen concentration and mortality rate were observed among treatments.