Keywords : Brain

Histopathological effect of fluoxetine drug on the brain of pregnant mice and their embryos

Baidaa Barwarei

Iraqi Journal of Veterinary Sciences, 2020, Volume 34, Issue 1, Pages 71-76
DOI: 10.33899/ijvs.2019.125467.1006

The present study was designed to identify the histopathological effect of fluoxetine (fluoxetine hydrochloride) on the pregnant mice brain and their fetuses as well as recording weight changes at doses of 60 and 80 mg/kg of body weight which were administrated to the pregnant mice from the 7th up to the 18th day of pregnancy and once a day. The results showed histopathological lesions in the adult pregnant mice brain at the dose of 60 mg/kg. induced massive necrotic area of neurons in the cerebral cortex, necrosis of the molecular layer cells while the dose of 80 mg/kg the changes include vasogenic edema in the sub cortical area, severe degeneration and necrosis of the cortex. The lesions in cerebellum were more severe than recorded in the cerebrum. The results also showed the presence of many lesions in the fetus brain at the dose 60 mg/kg and they were degeneration, necrosis of many neurons in the cerebrum while at the dose of 80 mg/kg. There were increase of degeneration and necrosis in the cortical area of fetus brain. In conclusion, the use of fluoxetine in pregnant mice caused decrease in body weight and Histopathological changes in the brain of both of the mothers and their embryos, thus the use of antidepressant by pregnant woman can be harmful for the mothers and the fetus.

Diagnostic study for Listeria monocytogenes isolated from brain and meat of sheep in Mosul city

Sumaya Aldabbagh

Iraqi Journal of Veterinary Sciences, 2019, Volume 33, Issue 2, Pages 51-55
DOI: 10.33899/ijvs.2019.163087

This study included collect of 150 samples from brain and meat of sheep from the slaughterhouse and local butchers shop in Mosul city. 50 sample from each (brain, cutting meat, and minced meat) which used for detection of listeria monocytogenes. The International Standard Organization (ISO) methods were used for isolation. The isolated bacteria were diagnosed according to bacterial morphology, culture, and biochemical characteristics. 10 isolates were obtained, which included 2(4%) isolates from the brain of sheep, 3 (6%) isolates from cut meat and 5(10%) from minced meat. Virulence factors tests were used for bacterial isolates which include, lecithinase, lipase, protease, esterase, and hemolysin. Antibiotic sensitivity test for bacterial isolates was also used for some antibiotics. The results indicated that all isolates were sensitive to Ampicillin, Gentamycin, Chloramphenicol, and resistant to Nalidixic acid. However, they showed variant sensitivity to other antibiotics. In conclusion, this study documented that L monocytogenes can be isolated from brain and meat of sheep in Mosul city.

Some biochemical effects of Aloe vera leaves on tissues in normal mice

S. H. Rashed; S. A. Al-Ameen; M. G. Matti

Iraqi Journal of Veterinary Sciences, 2010, Volume 24, Issue 2, Pages 93-97
DOI: 10.33899/ijvs.2010.5605

This research was carried out mainly to investigate the effects of the aqueous extract and proteinous fractions of Aloe vera leaves on cholesterol, acetycholinesterase in brain, glycogen, glutathione in liver and malonaldehyde levels in heart in normal male albino mice. The antioxidant properties and inhibition of acetylcholine-sterase in tissue were detected. Intraperitoneal administration of Aloe vera extract in concentration of 400 mg/kg significantly decreased the levels of AchE in brain by (-88.27%) and glutathione content in liver by (-35.48%), and increased the levels of glycogen in liver and malonaldehyde in heart by (22.60%, 85.50%) respectively. At a concentration of 300 mg/kg Aloe vera extract significantly increased the level of cholesterol in brain by (24.39%). These results clearly show the antioxidant property of the extract of Aloe vera leaves.