Keywords : liver


Effects of Newcastle disease vaccine on the liver and antioxidant enzymes of chicks

N. G. Mustafa

Iraqi Journal of Veterinary Sciences, Volume 32, Issue 2, Pages 243-247
DOI: 10.33899/ijvs.2019.153856

Newcastle disease is a highly contagious disease of domestic and wild birds result in huge economic losses due to extreme morbidity and mortality. The aim of this paper is to explore the possibility of the harmful impact of Newcastle disease vaccine on certain biochemical profiles regarded to chicken liver. This study conducted during January-April 2014, one day old - 53 chicks were divided into two groups; vaccinated (with Newcastle disease vaccine) group at the age of 1, 3, and 7 days and unvaccinated group. Results show damaging effects of vaccination on the liver glycogen and malondialdehyde concentrations, serum superoxide dismutase, catalase, glutathione peroxidase, gamma-glutamyl transferase, alanine transaminase, and aspartate transaminase activities. In contrast, studied parameters look to return to their usual range at the age of 30 days. From the convincing outcome of our investigation, it can be concluded that Newcastle disease vaccination has a detrimental influence on the liver of chickens, nonetheless this effect can be overwhelmed by the time.

Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails

Saevan Saad Al-Mahmood; S.M. Al-Abady

Iraqi Journal of Veterinary Sciences, Volume 31, Issue 2, Pages 67-71
DOI: 10.33899/ijvs.2017.145567

In present study, we aimed to investigate the pathological changes induced by subchronic oral toxicity induced by sub lethal dose of Di (2-ethyl hexyl) phthalate (DEHP) in Japanese common quail. Forty male quails at one day old were divided randomly into two equal groups, the first group (treated group) was orally administrated by 10% of LD50 of DEHP (557.41 mg/kg of body weight) for 42 days, while second group (control group) left without treatment throughout experiment period. The results of current study showed that there is congestion of kidney, microscopically they showed presence of hyaline degeneration in renal tubules, glomerulosclerosis, wide spread of degenerative and necrotic lesions in renal tubules, hemorrhage, infiltration of inflammatory cell especially macrophages and lymphocytes in interstitial tissue of kidney. While grossing of liver showed hepatomegaly with hemorrhage, microscopically the sections showed wide distributing of vacuolar degeneration (fatty change) in different size and shape of vacuoles in cytoplasm of affected hepatocytes, infiltration of inflammatory cells mainly macrophages and lymphocytes. In conclusion, the oral administration of DEHP at dose 557.41 mg/kg of body weight for 42 days induced degenerative and necrotic irreversible changes in both kidney and liver of Japanese quail that affect their health and production.

Comparative histopathological effects of aqueous, hexane extracts of Iraqi sweet almond (Prunus amygdalus) with atorvastatin for treating hyperlipidemia induced in mice

L.A. Kafi; N.TH.N. Al- Ezzi

Iraqi Journal of Veterinary Sciences, Volume 31, Issue 1, Pages 13-21
DOI: 10.33899/ijvs.2017.126705

This research was carried out to find out the treatment impact of aqueous and hexane extracts of sweet almond (Prunus amygdalus) on some histopathological indicators of heart, aorta and liver related to hyperlipidemia that induced in mice and compare them with Atorvastatin. Sweet almond was dried and grinded by an electrical grinder to form fine crude powder that extracted by two ways: by using 95% hexane and water by using the distilled water with Soxhlet apparatus. Forty mature mice were randomly divided into 8 groups (5 mice per group) and treated every day for 60 days, the first group was fed and drank normally and regarded as a negative control group, a second group was given polypropylene glycol offered as negative control group, third group was given tap water containing 0.5% of hydrogen peroxide and 1% of cholesterol in the feed for 60 days for induction of hyperlipidemia and offered as positive control group. Hyperlipidemia was induced in the other five groups as in the third group. The treatment of hyperlipidemia was done by using hexane extract at a dose of 500 mg/ kg of body weight and aqueous extract of sweet almond with three different doses (500, 750 and 1000) mg/ kg of body weight and compared with the other group that treated with atorvastatin 20 mg/ kg B.W. as antihyperlipidemic drug. The outcomes discovered that histopathological changes of heart, aorta and liver exposed to hydrogen peroxide and cholesterol revealed congested blood vessels with inflammation relevant cells in their lumen with necrosis of hepatic cells and inflammation relevant cells collected in sinusoids and inner surfaces of the blood vessels and infiltration of macrophages and lymphocytes in the liver moreover to the infiltration of mononuclear cells in the heart while in the aorta showed the vacuolation in the sub intimae and vacuolation and increase the thickness of intimate layer. Furthermore, inflammation relevant cells particularly infiltration around aorta. While therapy with almond extracts and Atorvastatin lead to valuable changes in therapy of damaging happened in the heart, aorta and liver induced with hyperlipidemia. In addition a dose of 1000 mg/kg of aqueous extracts of sweet almond was the best in treatment of hyperlipidemia.

Metalic foreign body in the liver of cow: a case report

O.A. Abdullah; H.Kh. Ismail

Iraqi Journal of Veterinary Sciences, Volume 28, Issue 2, Pages 109-111
DOI: 10.33899/ijvs.2014.117978

On necropsy of a two years old clinically healthy cow admitted to Mosul abattoir at postmortem inspection slaughtering establishment a metalic foreign body (as a piece of wire) was identified in the region of the liver. Gross examination revealed multiple abscess involving the liver, as well a large area of necrosis around foreign body penetration. Microscopically
Suppurative inflammation in addition to foreign body granulomatous reaction.