Keywords : Rabbit

Anatomical study of arterial blood supply of the brain in local breed rabbit

Adnan A. Alhasso

Iraqi Journal of Veterinary Sciences, In Press
DOI: 10.33899/ijvs.2021.129231.1636

Current work aims to investigate the brain blood supply of the local rabbit, where 14 rabbits of both sexes were used with weights ranging from 3-3.5 kg. This study revealed that the rabbit's brain is supplied by the vertebral and internal carotid artery (ICA). The union of the vertebral arteries creates the basilar artery that runs on the ventral surface of the pons and medulla oblongata, forming at its end the posterior communicating arteries (PCA), as well as at the path of the basilar artery from which the following arteries are formed, which are the anterior cerebellar arteries, pons arteries, 1st posterior cerebellar artery, 2nd posterior cerebellar artery, and the medullary arteries. The ICA enters the cranium through the foramen lacerum, forming the anterior carotid network, from which an artery exits anteriorly, called the intracranial part of the ICA, and caudally exits the (PCA). The following arteries are created from the intracranial part of the ICA, which is the accessory anterior communicating artery that connects with the posterior communicating artery and the posterior cerebral artery (PCEA) forming the closed circle of Willis, the middle cerebral artery is also created anteriorly and laterally to distributed on the two cerebral hemispheres of the brain, as well as the anterior cerebral artery which directed forward to gives the marginal artery which represents the first terminal branch of the anterior cerebral artery, and at the marginal artery going toward the olfactory tract and then to the olfactory bulb from which the internal ethmoidal artery is created. The anterior communicating artery originates from the anterior cerebral artery and it is a small artery communicating the left and right anterior cerebral arteries with each other, and the posterior cerebral artery originates from the PCA, as well as the anterior cerebellar arteries arising from the PCA and accessory posterior communicating artery (APCA) and the anterior part of basilar artery, to supply the hemispheres of the cerebellum and the cerebellar vermis.

Pathological and biological effects of treatments with lambda-cyhalothrin in rabbits

Assia BOUMEZRAG; Houari HEMIDA; Fadhela Amina BOUMEZRAG; Fadh SMAIL; Sekhou CISSE

Iraqi Journal of Veterinary Sciences, 2021, Volume 35, Issue 3, Pages 443-450
DOI: 10.33899/ijvs.2020.126977.1425

Lambda-cyhalothrin (LCT) is a type II pyrethroid insecticide, which is widely used to control a large variety of agricultural pests throughout the world as well as in Algeria. The aim of this study was to investigate the effects of LCT exposure on body weight, hematological and blood biochemical parameters and to evaluate histopathological changes in some organs. Twelve (12) healthy local rabbits with a mean body weight of 1.8 kg were divided into three groups of four each: First group was kept as control (CTRL), second group (LCT 10) and third group (LCT 20) were given oral LCT at 10 and 20 mg/kg b.w, respectively three times a week for 25 days. The results showed no significant difference in mean body weight between groups. Blood analysis revealed no significant variation in hemogram between LCT-treated groups and control group. Serum biochemical analysis revealed a significant increase (P˂0.05) in total cholesterol content and glucose in LCT10 and LCT20, respectively. Total protein increased significantly (P˂0.0001) in LCT 20 group. While a very high increase (P˂0.0001) in the activity of asparatate aminotranferase (AST) was recorded in both treated groups, no change was observed in the activity of alanine aminotransferase (ALT). LCT treatment exhibited severe histopathological changes in liver, kidney, lung and brain. It is concluded from the study that LCT produced serious toxic pathological alterations and metabolic dysfunctions in rabbits.

In Vivo evaluation of the novel nanocomposite porous 3D scaffold in a rabbit model: hematology and biochemistry analysis

S. J. Mahmood; Md. Z. Zakaria; I. Sh. Abdul Razak; L. M. Yusof; A. A. Abubakar; Z. K. Mahmood; M. Q. Bin Ab Latip

Iraqi Journal of Veterinary Sciences, 2018, Volume 32, Issue 2, Pages 219-230
DOI: 10.33899/ijvs.2019.153853

Issues of safety are very crucial with biomaterials and medical devices. Sixteen male New Zealand White rabbits equally into four groups: Group A, rabbits had part of their radial bone (2 cm, mid shaft) and left empty as a control. Group B, rabbits were implanted with scaffold 5211. Group C, rabbits were implanted with scaffold 5211GTA+Alginate. Group D, rabbits were implanted with 5211PLA. All scaffolds were prepared by freeze-drying method. Blood samples were collected at day 0 and 1st, 2nd, 3rd, 4th and 8th week after implantation. The blood examination included complete hemogram and certain serum biochemical parameters. The results showed that there was no significant difference (P>0.05) among each treatment group in comparison with control group (day 0). However, red blood cells, hemoglobin, packed cell volume, mean corpuscular hemoglobin concentration, monocyte, plasma protein, inorganic phosphate, sodium, chloride and urea were significantly increased (P<0.05) among treatment groups at week 8. An abnormal architecture of viscera was observed in all animals, thus indicating a form of toxicity related to the degrading scaffold materials. The severity of histopathological lesions in viscera was not coated polymers dependent nor development materials. In conclusion, implantation of 5211 scaffold with or without coated framework has a significant impact on histopathological and certain hematological and biochemical parameters.