Keywords : kidney

The histological and histochemical changes in the kidney of rabbit induced by diazinon

S. A. Sadiq; M. T. Jarjees

Iraqi Journal of Veterinary Sciences, Volume 32, Issue 2, Pages 303-308

Diazinon (DZN) is a commonly used Organophosphorus (OP) pesticide to control a variety of insects in agriculture and in the environment. The aim of this project is to study the effects of organophospherous pesticide (Diazinon) on histological and histochemical of kidney in male rabbit. The present study is based upon observations made on 24 male Baladi rabbits, which was divided into: 3 groups: Eight animals each, the whole body of the rabbit was dipped in 10 liters of the diazinon solution, while sparing the head for 10 seconds. Group one (control group) was dipped in water only. Animals of Group 2; were dipped in diazinon solution dipped every 2 days for 4 weeks, and Group 3 were dipped in diazinon solution every 7days for two months. Decreased in body weight was noticed in group 2 and group 3 may be due to increases in the exposed doses and increased accumulation of DZN in the blood of the exposure animals. Histological changes in group 2 and 3 are similar, renal tubules were severely damaged with cytoplasmic vacuolation and atrophy of some glomeruli. Blood capillaries in between the degenerated tubules were congested; the urine spaces are widening, and fibrosis inters tubules in group 3 only. Exposure of animals to diazinon caused extensive changes in histopathologicaly as well as histochemicaly in the kidney of group 2 and group 3. But very marked changes in group 3.

Pathological study of subchronic oral toxicity induced by Di (2- ethyl hexyl) phthalate in Japanese quails

Saevan Saad Al-Mahmood; S.M. Al-Abady

Iraqi Journal of Veterinary Sciences, Volume 31, Issue 2, Pages 0-0

In present study, we aimed to investigate the pathological changes induced by subchronic oral toxicity induced by sub lethal dose of Di (2-ethyl hexyl) phthalate (DEHP) in Japanese common quail. Forty male quails at one day old were divided randomly into two equal groups, the first group (treated group) was orally administrated by 10% of LD50 of DEHP (557.41 mg/kg of body weight) for 42 days, while second group (control group) left without treatment throughout experiment period. The results of current study showed that there is congestion of kidney, microscopically they showed presence of hyaline degeneration in renal tubules, glomerulosclerosis, wide spread of degenerative and necrotic lesions in renal tubules, hemorrhage, infiltration of inflammatory cell especially macrophages and lymphocytes in interstitial tissue of kidney. While grossing of liver showed hepatomegaly with hemorrhage, microscopically the sections showed wide distributing of vacuolar degeneration (fatty change) in different size and shape of vacuoles in cytoplasm of affected hepatocytes, infiltration of inflammatory cells mainly macrophages and lymphocytes. In conclusion, the oral administration of DEHP at dose 557.41 mg/kg of body weight for 42 days induced degenerative and necrotic irreversible changes in both kidney and liver of Japanese quail that affect their health and production.