Keywords : Xylazine


Oral imipramine and intravenous xylazine for pharmacologically-induced ejaculation in donkeys

U.T. Naoman; A.J. Ali

Iraqi Journal of Veterinary Sciences, Volume 26, Issue 2, Pages 81-83
DOI: 10.33899/ijvs.2012.67461

The aim of this study is to evaluate using chemical method by oral imipramine and intravenous injection of xylazine for semen collection from donkeys in a field condition. Five mature male donkeys were used in this study weighting 120-150 Kg, aged 2-4 years, kept in the animal house of the Veterinary Collage, University of Mosul. Semen collections were performed by administration of a combination of imipramine hydrochloride 3 mg/kg. BW orally then 2 hours later, intravenous xylazine hydrochloride was injection as 1.1 mg/kg BW then semen was collected in ballistic tube. A total of 29 ejaculates from 30 trials were collected successful with a successful rate up to 96.6%. Semen characteristics of these donkeys were volume 60.1±2.9 ml, individual motility 53.5±2.0%, sperm concentration 60.2±1.7×106/ml sperm abnormalities 9.5±3.3%, live sperm 57.2±4.5% and PH 7.3±1.8. It could be concluded that, chemical method could be used successfully for semen collection from donkeys.

Synergism of the analgesic activities of tramadol with α2 adrenoreceptor agonist xylazine in mice

G. A. Taqa

Iraqi Journal of Veterinary Sciences, Volume 26, Issue 2, Pages 109-113
DOI: 10.33899/ijvs.2012.67485

The present study was undertaken to evaluate the antinociceptive interaction between tramadol and xylazine. The antinociceptive effect of intraperitoneal (I.P) administration of the drug alone or in combination was evaluated using the mouse hot-plate test. Administration of tramadol in fixed dose (20mgkg) I.P with different doses of xylazine (0, 2, 4, 8) mgkg I.P significantly referred synergism of the antinociceptive effect of tramadol depending on the dose of xylazine. There was an increased the antinociceptive maximum possible effect (%MPE) from (27.08%) to (85.4%). The effective dose that produce 50% antinociceptive (ED50) were evaluated for each drug alone or in combination. The present study found that the administration of tramadol and xylazine markedly reduced the median effective dose (ED50) of both drugs for antinociceptive effect in mice. The result of this study demonstrated that there was synergism (super-additive) interaction between tramadol and xylazine.