Author : Ibrahim, N.K.
Effect of diphenhydramine on the changes in cholinesterase activity and intestinal motility induced by imidocarb in chicks
Iraqi Journal of Veterinary Sciences,
2012, Volume 26, Issue Suppl. II, Pages 47-53
This study examines and evaluates the interaction between imidocarb and diphenhydramine on the level of cholinesterase activity and small intestinal transit (SIT) in chicks. Imidocarb at 45 mg/kg,s.c. significantly inhibited plasma and brain cholinesterases, 30 min after injection by 69 and 21%, respectively. Diphenhydramine at 5 mg/kg, s.c significantly inhibited plasma and brain cholinesterase by 29.7 and 35.7%, respectively and significantly decreased the inhibitory effect of imidocarb on plasma cholinesterase by 33.2%. Imidocarb at 40 mg/kg, s.c. significantly increased SIT 15 and 30 min after injection by 92, 100%, respectively. Diphenhydramine at 5 and 10 mg/kg, s.c., 15 min before imedocarb at 40mg/kg, s.c. significantly decreased SIT produced by imidocarb alone by 80.6 and 70.5 %, respectively and prevented the SIT when given immediately after imedocarb at 40 mg/kg, s.c. by 100%.The data revealed that diphenhydramine has a beneficial effect in controlling the SIT modulated by imidocarb in chicks and there was no adverse interaction between two drugs at the level of cholinesterase.