is belonged to Mimosaceae family,
commonly known as mesquite.
It was chosen to investigate their effect on α-glucosidase inhibitory activity (in-vitro
), serum glucose and liver functions. Roots, fruits, and leaves of P. farcta
, were extracted by n
-hexane, ethyl acetate, and methanol. α-glucosidase inhibition was analyzed by using ELISA technique then half maximal inhibitory concentration IC50
was found. The blood glucose levels were determined with a glucose analyzer model. The serum alkaline phosphatase (ALP), Alanine transaminase (ALT), aspartate aminotransferase (AST) and serum total bilirubin (TB) were estimated by using the Cobas diagnostic kit with a fully automated chemical analyzer. Diabetes was done by a single dose of 120 mg alloxan/kg b.w with subcutaneously injection. Ethyl acetate extracts of P. farcta
showed the higher α-glucosidase inhibitory activity, and the best one was root extract. Treatments of the alloxan-induced diabetes rats were done by daily oral administration of different concentrations with P. farcta
extracts of ethyl acetate for 28 days and the dose 200 mg/kg BW was the effective one. The root extract was the best one for reduction of serum glucose followed by leaves then fruits. Administration of root extract of P. farcta
showed a decrease in the levels of ALP and TB in alloxan-induced diabetes rats. The fruit extract of P. farcta
showed decreasing in the level of ALP in alloxan-induced diabetes rats. In conclusion, the P. farcta
extracts for ethyl acetate have properties of hypoglycemic effect as well as improving some parameters related with diabetic complications of liver functions.