is belonged to Mimosaceae family,
commonly known as mesquite.
It was chosen to investigate their effect on α-glucosidase inhibitory activity (in-vitro
), serum glucose and liver functions. Roots, fruits, and leaves of P. farcta
, were extracted by n
-hexane, ethyl acetate, and methanol. α-glucosidase inhibition was analyzed by using ELISA technique then half maximal inhibitory concentration IC50
was found. The blood glucose levels were determined with a glucose analyzer model. The serum alkaline phosphatase (ALP), Alanine transaminase (ALT), aspartate aminotransferase (AST) and serum total bilirubin (TB) were estimated by using the Cobas diagnostic kit with a fully automated chemical analyzer. Diabetes was done by a single dose of 120 mg alloxan/kg b.w with subcutaneously injection. Ethyl acetate extracts of P. farcta
showed the higher α-glucosidase inhibitory activity, and the best one was root extract. Treatments of the alloxan-induced diabetes rats were done by daily oral administration of different concentrations with P. farcta
extracts of ethyl acetate for 28 days and the dose 200 mg/kg BW was the effective one. The root extract was the best one for reduction of serum glucose followed by leaves then fruits. Administration of root extract of P. farcta
showed a decrease in the levels of ALP and TB in alloxan-induced diabetes rats. The fruit extract of P. farcta
showed decreasing in the level of ALP in alloxan-induced diabetes rats. In conclusion, the P. farcta
extracts for ethyl acetate have properties of hypoglycemic effect as well as improving some parameters related with diabetic complications of liver functions.
This study aimed to investigate the effects of ethyl acetate Prosopis farcta
extracts on some complications associated with diabetes in rats. The experimental rats of 1.5-2 months old that weighed 190-220 g were randomly divided into six groups of seven animals each. Body weight, serum glucose, hematological changes and lipid profiles were studied. Alloxan was used of induction diabetes in rats.
252 rats were used anddifferent doses of the ethyl acetate extracts of roots, fruits, and leaves of P. farcta
were orally administered daily for 28 daysfornormal and diabetic rats and the effective dose was 200 mg/kg BW for each kind of extracts. The results showed that administration of root, leaves and fruit extracts of P. farcta
caused improvement in body weight, blood glucose, red blood cells (RBCs), hemoglobin (Hb), mean corpuscular hemoglobin (MCH), hematocrit (HCT orPCV) in alloxan diabetic rats in insulin like treatment manner, with the most effective improving effect for roots extract. Regarding to the effects on total and differential white blood cell (WBC) count, administration of extracts caused decrease in the total WBC and neutrophil count. Administration of root, leaves and fruit extracts of P. farcta,
showed suppression in total cholesterol (TC), triglyceride (TG), very low-density lipoprotein (VLDL-C) and low-density lipoprotein (LDL-C), and increasing in high density lipoprotein (HDL-C) of alloxan diabetic rats. In conclusion, the P. farcta
extracts possesses properties of improving some health complications accompanied diabetes in rats.